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    3. 首頁 > DNA
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      • DNA的非線性動力學特性和它的功能

        用新建立的非線性動力學模型研究了DNA的非線性特性及它的復制與遺傳,轉錄和轉譯等生物功能.這個新的模型強調了堿基氫鍵中的氫原子的獨特作用,使用了三個動力學變量來描述氫原子在雙Morse勢中的振動及堿基的振動與轉動,并充分考慮了三個運動模之間的耦合效應.應用這模型得到了復制與轉錄的特性,說明了DNA的分型特征及D-DNA-A-DNA以及B-DNA-Z-DNA等的相變機制及特性....

        2020-08-31 10:42:30瀏覽:23 DNA孤子動力學特性復制與遺傳轉錄與轉譯分型與相變

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      • 聚賴氨酸-聚乙二醇-聚賴氨酸與DNA聚離子復合物膠束的研究

        將聚(Nε-芐氧羰基賴氨酸)-聚乙二醇-聚(Nε-芐氧羰基賴氨酸)(PLL(Z)-PEG-PLL(Z))中的氨基去保護得到兩端為聚陽離子的嵌段共聚物聚賴氨酸-聚乙二醇-聚賴氨酸(PLL-PEG-PLL),并對其與DNA結合形成的聚集體的性質進行了研究.結果表明:PLL-PEG-PLL與DNA形成了聚離子復合物膠束;DNA與PLL通過靜電作用形成核,PEG包裹在其外面,得到的聚離子復合物膠束為均相體系,即使在化學計量點也不會沉淀,保持著很好的流動性和穩定性,這一點對基因治療是很重要的;而且隨著PLL段的增加,包覆效果更好;聚離子復合物膠束使得DNA具有較強的核酶抗性;大小在10~35nm之間,呈球形;聚離子復合物膠束能夠用于基因的傳遞,使基因在昆蟲細胞系SF9中能夠表達出蛋白質....

        2020-07-10 14:39:05瀏覽:47 聚賴氨酸聚乙二醇嵌段共聚物DNA聚離子復合物膠束

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      • 64. Study on the DNA damage induced by coal tar pitch fume extracts in rat alveolar macrophage and i

        The carcinogenic mechanism of coal tar pitch (CTP) as a recognized carcinogen has been studying. It is widely believed that the carcinogenicity of CTP is based on the genotoxicity of CTP. In the process of carcinogenesis caused by extrinsic chemical substance, the DNA damage mainly occurred in the initiation phase. UP to now, the most sensitive detecting endpoint for DNA damage is to detect DNA single strand breaks. The single cell gel electrophoresis has been rapidly becoming a widely used analytical procedure during the last few years, which can detect DNA strand breaks. The method is a fast, relatively inexpensive, easy to perform, non-radioactive, and very sensitive method. This method suits to different tests in vitro or in vivo. Virtually any eukaryotic cell, which could be made into single cell suspensions, can be processed for analysis of DNA damage using the single cell gel electrophoresis. The aim of the study is to investigate the role of DNA damage induced by CTP fume in rat AM, to examine the changes of ROS, MDA and SOD, and to explore the mechanism of DNA damage by CTP fume. The present study is in favor of studying the mechanism of mutagenesis and carcinogenesis induced by CTP. Method: The healthy male Wistar rats were anesthetized intraperitoneally with 40 mg pentobarbital sodium per kilogram of body weight. The animals were exanguinated by excising femoral, and collected the rat alveolar macrophage by Joseph's method. The concentration of AM had been regulated to 1.5×106 cell/ml. AMs, which had been cultured in 24-well culture plate, were divided into 4 groups. These cells were exposured to 5.0 μg/ml extracts of coal tar pitch fume, and contacted with 500 μM, 1 000 μM, and 2 000 μM of GSH respectively. These cells were divided into 4 groups. After incubation 24 hours, the indexes that had been used above were measured. Results: ①The DNA strand breaks induced by coal tar pitch fume extracts: After undergoing electrophoresis, the ‘comet’ cells are seldom in control group, but the ‘comet’ cells increased significantly in experimental groups. When the concentration of CTP fume extracts increased from 0 to 10.0 μg/ml, the incidences of ‘comet’ cell increased from 6.0% to 92.0%. There were significant differences in all groups (P...

        2020-06-12 16:19:30瀏覽:1390 SinglecellgelelectrophoresisDNAdamagealveolarmacrophagecoaltarPitch

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      • 生物軟物質研究的新進展

        文章對近年來中科院物理研究所軟物質物理實驗室生物軟物質研究的部分新進展做一簡略介紹,包括DNA單分子研究,DNA與組蛋白的相互作用動力學研究,生物分子馬達的運動機制研究,解旋酶與DNA的結合以及解旋DNA的動力學研究,朊病毒片段聚集的分子動力學研究,蛋白質折疊動力學的脈沖升溫-時間分辨光譜研究,光合細菌外周捕光天線膜蛋白的拓撲結構研究等....

        2020-06-12 15:41:09瀏覽:1387 生物軟物質DNA蛋白質動力學軟物質物理

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      [!--page.stats--] 被公玩弄的年轻人妻

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